Signs and symptoms An lithograph of a woman diagnosed with depression Major depression significantly affects a person's family and personal relationships, work or school life, sleeping and eating habits, and general health.
The DCRP comprises a large group of experienced researchers, as well as promising young trainees and junior faculty.
The group has generated countless clinical reports and conducted numerous pilot studies and large controlled trials since its inception.
CRP researchers have received significant funding from both the National Institute of Mental Health and industry sponsors. If any of these studies interest you, please call us at to learn more.
All inquiries will be kept confidential. Effects of Mindfulness Training on Brain Mechanisms in Unipolar Depression DCRP is conducting a clinical research study evaluating the effects on the brain of two different 8-week programs for people suffering from depression.
The MBCT training program consists of weekly classes that combine cognitive therapy with mindfulness meditation. Mindfulness meditation cultivates present moment awareness to approach thoughts and feelings in a non-judgmental, self-compassionate, and overall accepting way.
If you are between and have no or limited previous experience with meditation, you may be eligible for this study. You may be eligible to participate in a research study at Mass General.
We are studying the brain chemistry of people who get better taking an FDA-approved antidepressant medication and people who get better taking a placebo. Hot Yoga for Depressive Symptoms Have you been feeling down or depressed?
Do you no longer enjoy the things you used to? Are you interested in finding a new way to treat your depression? If so, you may be eligible to participate in a study using hyperthermic yoga hot yoga to treat depression.
We are conducting a study that examines whether hyperthermic yoga might be a good treatment option for people who are experiencing symptoms of depression. During the study, participants will be assigned to begin the yoga classes immediately or put on a waitlist prior to attending the yoga classes.
Participants will be asked to attend at least two hot yoga classes a week for eight weeks. Additionally, you will be asked to come to Mass General in downtown Boston for assessment visits, when you will meet with a clinician and complete several questionnaires.
For more information, please contact Regina at or rroberg mgh. Adapted CBT for Depression in Patients with Moderate to Severe Traumatic Brain Injury The purpose of this study is to develop an adapted version of cognitive behavioral therapy CBT specifically for individuals diagnosed with depression and have sustained a moderate to severe traumatic brain injury TBI.
For more information or to see if you might be eligible, please contact Garrett at or gthomas12 mgh. Neuroimaging Studies of Reward Processing Paid research on depression, stress, and the brain. Have you been feeling sad, blue or down?
Have you lost interest in activities you normally enjoy? McLean Hospital and Mass General researchers are looking for volunteers to understand the role of dopamine, a chemical that is naturally released by brain cells, in emotions and behavior.
Participating in this study will take up to 14 hours. We are seeking adults who are between the ages of years old, right-handed and not currently taking any prescription drugs for depression, anxiety, or ADHD.
If you are interested in participating, please contact Sean at or sboyden partners. Please include your phone number and some good times to reach you, and researchers will contact you to conduct a preliminary phone screen and to provide more information about the study.
Have you been unable to find relief with standard antidepressant medication? We are seeking patients with major depressive disorder MDD between the ages of 18 and 65 to participate in a new depression research study.
This study is testing whether the combination of the drugs brexpiprazole and intranasal ketamine can safely and effectively treat people who are already taking an antidepressant medication, but have not had a satisfactory response.
If you are interested in learning more about this study, please contact Richard at or rjnorton mgh. Comparative Effectiveness Research Trial The purpose of this research study is to compare the effect of augmenting an antidepressant with aripiprazole common brand Abilify or rTMS commonly referred to as Repetitive transcranial magnetic stimulation versus switching to venlafaxine XR common brand Effexor for participants who have tried an antidepressant in the past but has not helped their depression.
For more information, please contact Emma at or erhayden mgh. Do you want to improve your mood, outlook, or energy? You may be eligible for a short-term group therapy research study.
Participants in this confidential project will be interviewed by researchers, and participate in group therapy for 4 weekly sessions. This may include facilitated group discussions or learning mindfulness and guided imagery techniques.
If currently taking antidepressants, you will be asked to not change medications during 6 weeks of the study.Cochrane works collaboratively with contributors around the world to produce authoritative, relevant, and reliable evidence, in the form of Cochrane Reviews.
Psychological research suggests that cognitive behavior therapy (CBT), used alone or in combination with medical therapy, is the most effective treatment for depression. Management of depression may involve a number of different therapies: medications, behavior therapy, and medical devices.
Major depressive disorder, often referred to simply as "depression", is diagnosed more frequently in developed countries, where up to 20% of the population is affected at some stage of their lives.
According to WHO (World Health Organization), depression is currently fourth.
Background Patients with chronic forms of major depression are difficult to treat, and the relative efficacy of medications and psychotherapy is uncertain. Methods We randomly assigned adults. Cognitive behavioral therapy (CBT) is a type of psychotherapy which has become a crucial part of psychology.
While it was originally formulated as a treatment for depression, it is now involved in the treatment of many different disorders.
A depressive disorder is not a passing blue mood but rather persistent feelings of sadness and worthlessness and a lack of desire to engage in formerly pleasurable activities.